Features
• Nutritional support for the maintenance of healthy skeletal, cardiovascular and immune systems.
• Vitamin D3 aids in healthy calcium absorption and metabolism.
A pleiotropic vitamin
Vitamin D3 is pleiotropic, meaning it influences the expression of numerous genes throughout the body. Once metabolised to its active form 1,25(OH)2D, it binds to the vitamin D receptor (VDR), a transcription factor which, when activated, induces the vitamin D responsive genes distributed in many tissues throughout the body.3
Bone development and health
The major function of vitamin D is to maintain serum calcium concentrations within an acceptable range. Inadequate vitamin D levels contribute to low serum calcium, which in turn stimulates the parathyroid glands to increase the production and secretion of parathyroid hormone (PTH). This results in upregulation of osteoclast activity which causes calcium and phosphorus to be released from bone into the blood. Intestinal absorption of calcium and reabsorption of calcium by the kidneys is also increased.3,4
• Supplementation may help reduce the risk of falls in older adults which in turn may help reduce the risk of fractures.
• Vitamin D3 is involved in healthy prostate cell differentiation.
• Small, easy to swallow capsules.
Adults: Take 1 capsule daily or as directed by your healthcare practitioner
Each capsule contains:
Colecalciferol (vitamin D3) 25mcg
equiv. vitamin D3 1000IU
If symptoms persist consult your healthcare practitioner.
• Vitamin supplements should not replace a balanced diet.
• Mineral oil, orlistat or lipid-lowering drugs such as cholestyramine may affect absorption of fat-soluble vitamins including vitamin D. Supplement either one hour prior to, or 4-6 hours after, drug intake.
• Vitamin D may reduce the effectiveness of calcium channel blockers; caution is advised with concurrent use. Concomitant use of vitamin D with aluminium may increase aluminium absorption.
• Concurrent use of supplemental vitamin D3 with calcipotriene or thiazide diuretics may theoretically increase the risk of hypercalcaemia.
